According to a new study by Abebio, detecting Hepcidin concentration can discriminate the deficiency anemia due to iron deficiency and anemia caused by other diseases. The findings could help governments make better decisions about when to fill children with iron (There is a risk of iron supplementation for those who do not need, Because it will change the gut microbiota and cause or exacerbate malaria and other types of infection).
Anemia(Lack of hemoglobin in blood）Affecting 300 million preschool children all over the world，The most common cause is iron deficiency, But there may be anemia due to infection or inflammation, or due to deficiency of other nutrient. Anemia due to iron deficiency can benefit most from iron supplementatio, But identifying children with iron deficiency has been a challenge (Early childhood iron deficiency was associated with cognitive impairment, Iron supplementation has been shown to improve primary school age children’s IQ)
Hepcidin – a hormone that regulates iron levels in the body and blocks the absorption of iron in the diet. Can be used for the specific detection of anemia caused by iron deficiency. The researchers examined the concentrations of hepcidin in 3 groups of preschool children from Gambia and Tanzania, find that hepcidin concentration is low in children with iron deficiency anemia, but high in Children with non iron deficiency anemia. In some cases (Infection and inflammation) Will produce a lot of iron regulation has been adjusted iron- very like insulin secretion increasing due to glucose.
Based on these results, The researchers are currently conducting clinical trials to test whether hepcidin concentrations can be used as a marker of iron supplementation.